Aloxi (palonosetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Aloxi is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

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Do not use Aloxi if you are allergic to palonosetron. Before you receive Aloxi, tell your doctor if you have an electrolyte imbalance, a personal or family history of "Long QT syndrome," if you take a diuretic (water pill), or if you take a heart rhythm medication.

Tell your doctor if you have ever had an allergic reaction to dolasetron (Anzemet), granisetron (Kytril), or ondansetron (Zofran).

Call your doctor at once if you have uneven heartbeats while receiving Aloxi.