Vetmedin (pimobendan) is supplied as oblong half-scored chewable tablets containing 1.25 or 5 mg pimobendan per tablet. Pimobendan, a benzimidazole-pyridazinone derivative, is a non-sympathomimetic, non-glycoside inotropic drug with vasodilatative properties. Pimobendan exerts a stimulatory myocardial effect by a dual mechanism of action consisting of an increase in calcium sensitivity of cardiac myofilaments and inhibition of phosphodiesterase (Type III). Pimobendan exhibits vasodilating activity by inhibiting phosphodiesterase III activity.
Vetmedin should be administered orally at a total daily dose of 0.23 mg/lb (0.5 mg/kg) body weight, using a suitable combination of whole or half tablets. The total daily dose should be divided into 2 portions that are not necessarily equal, and the portions should be administered approximately 12 hours apart (i.e., morning and evening). The tablets are scored and the calculated dosage should be provided to the nearest half tablet increment.
Weight lbs Daily Dosage (mg) # of pills per day 1.25mg Administer (AM then PM)
5.5lbs(2.5kg) 1.25mg 1 ½ a pill every 12 hours
8.25bs(3.75kg) 1.875mg 1.5 1 pill & then a ½ every 12 hours
11lbs(5kg) 2.50mg 2 1 pill every 12 hours
16.5lbs(7.5kg) 3.75mg 3 1 & ½ pills every 12 hours
22lbs (10kg) 5.06mg 4 2 pills every 12 hours
Weight lbs Daily Dosage (mg) # of pills per day 5.0mg Administer (AM then PM)
22lbs(10kg) 5.06mg 1 ½ a pill every 12 hours
33lbs(15kg) 7.59mg 1.5 1 pill & then a ½ every 12 hours
44lbs(20kg) 10.12mg 2 1 pill every 12 hours
66lbs(30kg) 15.18mg 3 1 & ½ pills every 12 hours
88lbs(40kg) 20.24mg 4 2 pills every 12 hours